Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA.
Neuron. 2011 Sep 22;71(6):955-7. doi: 10.1016/j.neuron.2011.09.002. Epub 2011 Sep 21.
Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.
颗粒蛋白前体突变可导致额颞叶痴呆，但潜在的病理生理学仍在很大程度上未得到解释。格什温德及其同事在本期《神经元》杂志上的新数据揭示，Wnt/FZD2 信号通路是疾病病理的早期和关键贡献者。
