Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Clin Immunol. 2011 Dec;141(3):328-37. doi: 10.1016/j.clim.2011.08.014. Epub 2011 Sep 2.
Rheumatoid arthritis is a chronic autoimmune disease and affecting approximately 1% of the population. Human adipose-derived mesenchymal stem cells (hASCs) were recently found to suppress effector T cell and inflammatory responses and, thus, to have beneficial effects in various autoimmune diseases. In this study, we examined whether hASCs could play a protective and/or therapeutic role in collagen-induced arthritis (CIA). We showed that hASCs both prevented and treated CIA by significantly reducing the incidence and severity of experimental arthritis. We further demonstrated that treatment with hASCs inhibited the production of various inflammatory mediators, decreased antigen-specific Th1/Th17 cell expansion, and induced the production of anti-inflammatory cytokine interleukin-10. Moreover, hASCs could induce the generation of antigen-specific Treg cells with the capacity to suppress collagen-specific T cell responses.
类风湿关节炎是一种慢性自身免疫性疾病，影响大约 1%的人口。最近发现，人脂肪间充质干细胞（hASCs）可抑制效应 T 细胞和炎症反应，因此对多种自身免疫性疾病具有有益作用。在这项研究中，我们研究了 hASCs 是否可以在胶原诱导的关节炎（CIA）中发挥保护和/或治疗作用。我们表明，hASCs 通过显著降低实验性关节炎的发生率和严重程度，来预防和治疗 CIA。我们进一步证明，hASCs 的治疗可抑制各种炎症介质的产生，减少抗原特异性 Th1/Th17 细胞的扩增，并诱导抗炎细胞因子白细胞介素-10 的产生。此外，hASCs 可诱导具有抑制胶原特异性 T 细胞反应能力的抗原特异性 Treg 细胞的产生。
