Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R., Otto-von-Guericke Universität, Leipziger Str. 44, 39120 Magdeburg, Germany.
Eur J Radiol. 2013 May;82(5):768-72. doi: 10.1016/j.ejrad.2011.08.001. Epub 2011 Sep 25.
In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated.
In a prospective, double blinded, placebo controlled, cross-over randomized study the sensations of 34 volunteers before, during and after exposure to the static magnetic field with and without drug respectively placebo administration were quantified. Fast table motion was applied to increase the incidence of otherwise sparse reports of field related sensations.
The strength of vertigo can be reduced by the application of diphenhydramine.
Diphenhydramine, even at a low dose, reduces the strength of vertigo at ultra-high static magnetic fields, may be used preventively, and could pave the way to even higher field strength.
本研究旨在评估苯海拉明在降低 7T 超高静磁场引起的眩晕和恶心方面的潜力。
在一项前瞻性、双盲、安慰剂对照、交叉随机研究中，量化了 34 名志愿者在暴露于静磁场前后以及分别给予药物和安慰剂时的感觉。快速的桌子运动被应用于增加与磁场相关的感觉的稀疏报告的发生率。
苯海拉明的应用可以降低眩晕的强度。
即使在低剂量下，苯海拉明也能降低超高静磁场引起的眩晕强度，可预防性使用，并可能为更高的场强铺平道路。
