Department of Pharmaceutics and Pharmacy Practice, Dubai Pharmacy College, Dubai, UAE.
Acta Pharm. 2011 Sep 1;61(3):271-82. doi: 10.2478/v10007-011-0025-3.
The objective of the study was to develop a suitable trans-dermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated. Skin irritation of the candidate film was evaluated. Chitosan film (PPL 2 mg cm(-2), chitosan 2%, m/m, cineol 10%, m/m) was found nonirritant and achieved 88.2% release after 8 hours in phosphate buffer. Significant high (p < 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor), making it a promising trans-dermal delivery system for PPL.
本研究的目的是通过使用壳聚糖作为成膜剂来开发盐酸普萘洛尔（PPL）的合适透皮给药系统。对薄膜的药物浓度均匀性、厚度、水分吸收能力和皮肤生物黏附性进行了表征。考察了壳聚糖和 PPL 浓度以及不同渗透促进剂对薄膜中药物释放和渗透特性的影响。评价了候选薄膜的皮肤刺激性。壳聚糖薄膜（PPL 2mg·cm(-2)，壳聚糖 2%，m/m，桉油醇 10%，m/m）在磷酸盐缓冲液中 8 小时后释放 88.2%，无刺激性。与不含渗透促进剂的薄膜相比，该薄膜显著提高了 PPL 通过大鼠皮肤的渗透（约 8 倍的增强因子），使其成为 PPL 有前途的透皮给药系统。
