Paediatric Emergency Department, Cruces Hospital, Barakaldo, Spain.
Pediatr Infect Dis J. 2012 Jan;31(1):92-5. doi: 10.1097/INF.0b013e3182337ddb.
We performed a 7-year registry-based retrospective study. We included 1365 infants younger than 3 months of age with fever without a source; 81 (5.9%) had <5000 leukocytes/mm(3). Among the 1021 well-appearing 29- to 90-day-old infants, prevalence of serious bacterial infection (SBI) was 13.8% for those with a normal white blood cell count, 6.8% for those with leukopenia (odds ratio, 0.45), and 36.6% for those with leukocytosis (odds ratio, 3.59). None of the 9 well-appearing febrile neonates with leukopenia developed an SBI. Leukopenia, in well-appearing young febrile infants, should not be considered as an SBI risk factor.
我们进行了一项为期 7 年的基于注册的回顾性研究。我们纳入了 1365 名年龄小于 3 个月的发热但无明确病因的婴儿；其中 81 名（5.9%）白细胞计数<5000/mm(3)。在 1021 名外观良好的 29-90 日龄婴儿中，白细胞计数正常的婴儿中严重细菌感染（SBI）的患病率为 13.8%，白细胞减少症的婴儿为 6.8%（比值比，0.45），白细胞增多症的婴儿为 36.6%（比值比，3.59）。在 9 名外观良好的白细胞减少症发热新生儿中，均未发生 SBI。外观良好的年轻发热婴儿的白细胞减少症不应被视为 SBI 的危险因素。
