相似文献
1
SHARPIN is an endogenous inhibitor of β1-integrin activation.SHARPIN 是 β1 整合素激活的内源性抑制剂。
Nat Cell Biol. 2011 Sep 25;13(11):1315-24. doi: 10.1038/ncb2340.
2
Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1.Shapin 通过与β1 尾部和 Kindlin-1 形成复合物来抑制β1 整合素的激活。
Cell Commun Signal. 2019 Aug 20;17(1):101. doi: 10.1186/s12964-019-0407-6.
3
The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling.整合素β1尾部的 NPIY 基序决定了向外信号传导中 talin-1 的需求。
J Cell Sci. 2010 Apr 15;123(Pt 8):1216-26. doi: 10.1242/jcs.056549. Epub 2010 Mar 23.
4
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.Kindlin-2与踝蛋白协作激活整合素，并通过直接结合桩蛋白诱导细胞铺展。
Elife. 2016 Jan 27;5:e10130. doi: 10.7554/eLife.10130.
5
Amino acid motifs required for isolated beta cytoplasmic domains to regulate 'in trans' beta1 integrin conformation and function in cell attachment.分离的β细胞质结构域调节“反式”β1整合素构象及细胞黏附中功能所需的氨基酸基序。
J Cell Sci. 1999 Jan;112 ( Pt 2):217-29. doi: 10.1242/jcs.112.2.217.
6
Myosin-X and talin modulate integrin activity at filopodia tips.肌球蛋白-X 和 talin 在丝状伪足尖端调节整合素活性。
Cell Rep. 2021 Sep 14;36(11):109716. doi: 10.1016/j.celrep.2021.109716.
7
The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.踝蛋白的N端结构域与磷酸酪氨酸结合样结构域协同作用以激活β1和β3整合素。
J Biol Chem. 2008 Mar 7;283(10):6118-25. doi: 10.1074/jbc.M709527200. Epub 2007 Dec 28.
8
NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain.NPXY基序独立于踝蛋白与β1链的结合，控制着α5β1整合素在黏着斑中的募集。
J Cell Sci. 1997 Jun;110 ( Pt 12):1421-30. doi: 10.1242/jcs.110.12.1421.
9
Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.踝蛋白在输尿管芽发育过程中调节整合素β1依赖性和非依赖性细胞功能。
Development. 2017 Nov 15;144(22):4148-4158. doi: 10.1242/dev.149914. Epub 2017 Oct 9.
10
Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.踝蛋白1磷酸化激活β1整合素：促进前列腺癌骨转移的新机制。
Oncogene. 2015 Apr 2;34(14):1811-21. doi: 10.1038/onc.2014.116. Epub 2014 May 5.
引用本文的文献
1
Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions.整合素β1活性在人类多能干细胞状态转变过程中控制集落形态。
Stem Cell Reports. 2025 Jul 8;20(7):102538. doi: 10.1016/j.stemcr.2025.102538. Epub 2025 Jun 19.
2
The phosphatase PPM1F, a negative regulator of integrin activity, is essential for embryonic development and controls tumor cell invasion.磷酸酶PPM1F是整合素活性的负调节因子，对胚胎发育至关重要，并控制肿瘤细胞的侵袭。
BMC Biol. 2025 Jun 19;23(1):166. doi: 10.1186/s12915-025-02254-3.
3
Regulation of cell migration by extracellular matrix mechanics at a glance.细胞外基质力学对细胞迁移的调控一览。
J Cell Sci. 2025 Apr 1;138(7). doi: 10.1242/jcs.263574. Epub 2025 Apr 4.
4
SKA3 promotes lung adenocarcinoma progression via the EGFR/E2F1/SKA3/integrin β1 signaling loop.SKA3通过EGFR/E2F1/SKA3/整合素β1信号回路促进肺腺癌进展。
Mol Cell Biochem. 2025 Mar 8. doi: 10.1007/s11010-025-05242-x.
5
Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction.整合素及其相关蛋白作为机械信号转导的介质
Biomolecules. 2025 Jan 23;15(2):166. doi: 10.3390/biom15020166.
6
Integrins as Key Mediators of Metastasis.整合素作为转移的关键介质。
Int J Mol Sci. 2025 Jan 22;26(3):904. doi: 10.3390/ijms26030904.
7
Irisin reduces senile osteoporosis by inducing osteocyte mitophagy through Ampk activation.鸢尾素通过激活Ampk诱导骨细胞线粒体自噬来减轻老年性骨质疏松症。
iScience. 2024 Sep 26;27(11):111042. doi: 10.1016/j.isci.2024.111042. eCollection 2024 Nov 15.
8
The role and regulation of integrins in cell migration and invasion.整合素在细胞迁移和侵袭中的作用及调控
Nat Rev Mol Cell Biol. 2025 Feb;26(2):147-167. doi: 10.1038/s41580-024-00777-1. Epub 2024 Sep 30.
9
Focal adhesions contain three specialized actin nanoscale layers.黏着斑含有三个特殊的肌动蛋白纳米层。
Nat Commun. 2024 Mar 21;15(1):2547. doi: 10.1038/s41467-024-46868-7.
10
CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover.CD56/NCAM 通过促进整合素介导热激黏附转化来介导人 NK 细胞的迁移。
Mol Biol Cell. 2024 May 1;35(5):ar64. doi: 10.1091/mbc.E23-12-0463. Epub 2024 Mar 20.
本文引用的文献
1
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.SHARPIN 形成一个线性泛素连接酶复合物，调节 NF-κB 活性和细胞凋亡。
Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.
2
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.SHARPIN 是 NF-κB 激活线性泛素链组装复合物的一个组成部分。
Nature. 2011 Mar 31;471(7340):633-6. doi: 10.1038/nature09815.
3
Linear ubiquitination prevents inflammation and regulates immune signalling.线性泛素化可预防炎症并调节免疫信号转导。
Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.
4
A cell spot microarray method for production of high density siRNA transfection microarrays.一种用于生产高密度 siRNA 转染微阵列的细胞斑点微阵列方法。
BMC Genomics. 2011 Mar 28;12:162. doi: 10.1186/1471-2164-12-162.
5
Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.Sipl1 和 Rbck1 是 Eya1 的新型结合蛋白，在颅面发育中发挥作用。
Mol Cell Biol. 2010 Dec;30(24):5764-75. doi: 10.1128/MCB.01645-09. Epub 2010 Oct 18.
6
The Structure of the talin head reveals a novel extended conformation of the FERM domain.塔林头的结构揭示了 FERM 结构域的一种新颖的扩展构象。
Structure. 2010 Oct 13;18(10):1289-99. doi: 10.1016/j.str.2010.07.011.
7
Inhibition of NF-κB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice.抑制 NF-κB 信号通路可延缓 SHARPIN 缺陷型小鼠的嗜酸性粒细胞性皮炎。
J Invest Dermatol. 2011 Jan;131(1):141-9. doi: 10.1038/jid.2010.259. Epub 2010 Sep 2.
8
Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion.乳腺衍生生长抑制剂（MDGI）与整合素 α 亚基相互作用，抑制整合素活性和侵袭。
Oncogene. 2010 Dec 9;29(49):6452-63. doi: 10.1038/onc.2010.376. Epub 2010 Aug 30.
9
Unique and redundant functions of integrins in the epidermis.整合素在表皮中的独特和冗余功能。
FASEB J. 2010 Nov;24(11):4133-52. doi: 10.1096/fj.09-151449. Epub 2010 Jul 12.
10
Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.Shank-interacting protein-like 1 通过抑制 PTEN 促进人肿瘤细胞的肿瘤发生。
J Clin Invest. 2010 Jun;120(6):2094-108. doi: 10.1172/JCI40778. Epub 2010 May 10.
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