钯催化的苯并[d]恶唑 C-H 键与芳基磺酰氯的脱硫 C-芳基化反应。
Palladium-catalyzed desulfitative C-arylation of a benzo[d]oxazole C-H bond with arene sulfonyl chlorides.
机构信息
College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325000, People's Republic of China.
出版信息
Chem Commun (Camb). 2011 Nov 7;47(41):11522-4. doi: 10.1039/c1cc14718h. Epub 2011 Sep 23.
PMID:21947089
Abstract
A palladium-catalyzed direct desulfitative C-arylation of a benzo[d]oxazole C-H bond with arene sulfonyl chlorides is described. The procedure tolerates halo, cyano, nitro, trifluoromethyl, acetyl and acetylamino groups on the phenyl ring of sulfonyl chlorides, providing the arylation products in moderate to good yields. It represents a practical and attractive alternative for the synthesis of 2-aryl benzoxazoles.
摘要
钯催化的苯并[d]恶唑 C-H 键与芳基磺酰氯的直接脱硫 C-芳基化反应被描述。该方法可以容忍磺酰氯苯环上的卤代、氰基、硝基、三氟甲基、乙酰基和乙酰氨基等取代基，以中等至良好的收率提供芳基化产物。它为 2-芳基苯并恶唑的合成提供了一种实用且有吸引力的替代方法。
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