Villatte-Cathelineau B
Service du Pr G. Cathelineau, Hôpital Saint-Louis, Paris.
Diabete Metab. 1990;16(2 Pt 2):131-6.
The problem concerning the influence of pregnancy on diabetic retinopathy is still a matter for discussion. The questions are: can the pregnancy itself influence the onset of a retinopathy? and can a pregnancy worsen the prognosis of a retinopathy and if it is the case is there any difference regarding the type of the retinopathy: background or proliferative? Despite controversies in the literature, it seems that: If no retinopathy is present at the onset of the pregnancy, the risk for developing retinal complications is very low. A background retinopathy can worsens and may become proliferative. But improvement is often observed in post-partum. A proliferative retinopathy worsen very frequently and the proper management of patients with this type of retinopathy is of extreme importance regarding to the risk of complications and loss of vision. Before the advent of photocoagulation, the alternative to therapeutic abortion was pituitary ablation. Now, the photocoagulation became the treatment of choice for proliferative retinopathy with the same results in pregnant or non pregnant woman. But the proliferative retinopathy is associated with a high incidence of foetal morbidity. Some studies provide evidence that changes in background retinopathy may be related to the degree of diabetic control achieved during pregnancy. The rapidity of improvement in diabetic control may be critical. Diabetic women who are wishing pregnancies may undergo ocular examination with angiography. During pregnancy strict ocular examination is necessary through dilated pupils. Angiography does not seem to induce any side effect on pregnant women.
怀孕对糖尿病视网膜病变的影响问题仍有待探讨。问题如下:怀孕本身会影响视网膜病变的发生吗?怀孕会使视网膜病变的预后恶化吗?如果是这样,对于背景性或增殖性视网膜病变类型是否存在差异?尽管文献中存在争议,但似乎:如果怀孕开始时没有视网膜病变,发生视网膜并发症的风险非常低。背景性视网膜病变可能会恶化并可能发展为增殖性病变。但产后通常会观察到病情改善。增殖性视网膜病变经常恶化,对于这类视网膜病变患者的妥善管理对于并发症风险和视力丧失至关重要。在光凝治疗出现之前,治疗性流产的替代方法是垂体切除术。现在,光凝治疗已成为增殖性视网膜病变的首选治疗方法,对孕妇和非孕妇的效果相同。但增殖性视网膜病变与胎儿发病率高有关。一些研究表明,背景性视网膜病变的变化可能与孕期实现的糖尿病控制程度有关。糖尿病控制改善的速度可能至关重要。希望怀孕的糖尿病女性可能需要进行眼部血管造影检查。怀孕期间,通过散瞳进行严格的眼部检查是必要的。血管造影似乎不会对孕妇产生任何副作用。