Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):308-15. doi: 10.1176/jnp.23.3.jnp308.
The relationship between cognitive impairment and white-matter integrity in human immunodeficiency virus (HIV) remains poorly understood, particularly in clade C. The authors utilized diffusion tensor imaging (DTI) and a comprehensive neuropsychological evaluation to investigate the relationship between cognitive impairment and white-matter integrity in HIV-positive subjects with clade C HIV. Forty-four HIV-infected individuals and 10 seronegative subjects were compared, using a whole-brain, voxel-based approach to define fractional anisotropy (FA) and mean diffusion (MD). Compared with healthy-control subjects, the HIV-infected group exhibited decreased FA in the corpus callosum, superior longitudinal fasciculus, and cingulum and sagittal stratum. This study provides evidence that white-matter integrity is compromised in individuals infected with clade C HIV.
人类免疫缺陷病毒 (HIV) 感染者的认知障碍与脑白质完整性之间的关系仍不清楚，尤其是在 HIV 病毒 C 型组中。作者利用弥散张量成像（DTI）和全面的神经心理学评估，研究了 HIV 病毒 C 型组 HIV 阳性患者认知障碍与脑白质完整性之间的关系。通过全脑基于体素的方法比较了 44 名 HIV 感染个体和 10 名血清阴性对照者的各向异性分数（FA）和平均扩散率（MD）。与健康对照组相比，HIV 感染组的胼胝体、上纵束和扣带以及矢状层的 FA 值降低。本研究为 HIV 病毒 C 型组感染者脑白质完整性受损提供了证据。
