Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):358-61. doi: 10.1176/jnp.23.3.jnp358.
Major depression is a common diagnosis in older individuals. The authors present preliminary findings on the response to sertraline in depressed elderly patients with and without dementia. Previous research on antidepressant treatment in elderly patients suggests that it is effective in treating depression. The authors followed depressed patients with and without dementia. Treatment response was more marked in the subgroup without dementia, but there was no statistically significant difference in response between the two subgroups. Depressed elderly patients with dementia may improve on antidepressant treatment, although treatment response may be less robust than in depressed patients without dementia.
重度抑郁症在老年人中是一种常见的诊断。作者介绍了有和没有痴呆的老年抑郁症患者对舍曲林反应的初步发现。之前关于老年患者抗抑郁治疗的研究表明，它对治疗抑郁症是有效的。作者随访了有和没有痴呆的抑郁患者。无痴呆亚组的治疗反应更为明显，但两组之间的反应无统计学差异。患有痴呆的老年抑郁症患者可能会对抗抑郁治疗有所改善，尽管治疗反应可能不如没有痴呆的抑郁患者那么显著。
