Centre d'Immunologie Marseille-Luminy, Université de la Méditerranée, 13288 Marseille, France.
J Immunol. 2011 Nov 1;187(9):4411-5. doi: 10.4049/jimmunol.1101717. Epub 2011 Sep 23.
Subsets of dendritic cells (DCs) have been described according to their functions and anatomical locations. Conventional DC subsets are defined by reciprocal expression of CD11b and CD8α in lymphoid tissues (LT), and of CD11b and CD103 in non-LT (NLT). Spleen CD8α(+) and dermal CD103(+) DCs share a high efficiency for Ag cross-presentation and a developmental dependency on specific transcription factors. However, it is not known whether all NLT-derived CD103(+) DCs and LT-resident CD8α(+) DCs are similar despite their different anatomical locations. XCR1 was previously described as exclusively expressed on mouse spleen CD8α(+) DCs and human blood BDCA3(+) DCs. In this article, we showed that LT-resident CD8α(+) DCs and NLT-derived CD103(+) DCs specifically express XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. Therefore, CD8α(+) DCs and CD103(+) DCs belong to a common DC subset which is unequivocally identified by XCR1 expression throughout the body.
树突状细胞 (DC) 亚群根据其功能和解剖位置进行了描述。传统的 DC 亚群通过在淋巴组织 (LT) 中 CD11b 和 CD8α 的相互表达以及在非 LT (NLT) 中 CD11b 和 CD103 的相互表达来定义。脾脏 CD8α(+) 和皮肤 CD103(+) DC 在 Ag 交叉呈递方面效率很高，并且在发育上依赖于特定的转录因子。然而，尽管它们的解剖位置不同，是否所有 NLT 衍生的 CD103(+) DC 和 LT 驻留的 CD8α(+) DC 都相似尚不清楚。XCR1 以前被描述为仅在小鼠脾脏 CD8α(+) DC 和人类血液 BDCA3(+) DC 上表达。在本文中，我们表明 LT 驻留的 CD8α(+) DC 和 NLT 衍生的 CD103(+) DC 特异性表达 XCR1，并具有独特的转录特征，而与其组织来源无关。因此，CD8α(+) DC 和 CD103(+) DC 属于一个共同的 DC 亚群，该亚群通过全身表达 XCR1 来明确识别。
