Pediatrics. 2011 Oct;128(4):e1034-45. doi: 10.1542/peds.2011-1496. Epub 2011 Sep 26.
Appropriate prescribing practices for fluoroquinolones are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children becomes better defined. Earlier recommendations for systemic therapy remain; expanded uses of fluoroquinolones for the treatment of certain infections are outlined in this report. Although fluoroquinolones are reasonably safe in children, clinicians should be aware of the specific adverse reactions. Use of fluoroquinolones in children should continue to be limited to treatment of infections for which no safe and effective alternative exists.
氟喹诺酮类药物的合理处方实践至关重要，因为需要考虑不断变化的耐药模式、确定更多的治疗适应证以及更好地定义氟喹诺酮类药物在儿童中的毒性特征。本报告概述了氟喹诺酮类药物在某些感染治疗中的扩展用途，但仍应遵循早期的全身治疗建议。虽然氟喹诺酮类药物在儿童中相对安全，但临床医生应注意特定的不良反应。在儿童中使用氟喹诺酮类药物应继续限于治疗没有安全有效替代药物的感染。
