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Class II alloantigen induced on corneal endothelium. Role in corneal allograft rejection.

作者信息

Donnelly J J, Orlin S E, Wei Z G, Raber I M, Rockey J H

机构信息

Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.

出版信息

Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1315-20.

PMID:2194989
Abstract

The expression of Class II major histocompatibility complex (MHC) antigens on corneal cells can be increased in vitro by (gamma-interferon) and in vivo in inflammatory reactions. The expression of Class II MHC by corneal endothelium of New Zealand White (NZW) rabbits during the rejection of corneal allografts was demonstrated by immunoperoxidase staining. Class II MHC expression by corneal endothelial cells may facilitate rejection of corneal allografts.

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