[α-烯醇化酶在鼻咽癌组织中的表达]
[The expressions of alpha-enolase in the nasopharyngeal cancer tissue].
作者信息
Cheng Chao, Long Xiaobin, Li Xin, Xie Minqiang, Guo Menghe
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, Zhujiang Hospital, South Medical University, Guangzhou, 510282, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jun;25(12):554-6.
OBJECTIVE
To study the meaning of expressions of ENO1 in the nasopharyngeal cancer tissue.
METHOD
By using SP immunohistochemical methods.
RESULT
The positive expressions for ENO1 were 60.0% in the nasopharyngeal cancer tissues,significantly higher than that (27.5%, 11/40) of in inflammatory nasopharyngeal mucosa (P<0.05). The positive expression rate of ENO1 protein in stage T1 + T2 + T3 was higher than that of in patients with T4 (chi2 = 11.424, P<0.05). But there was no significant relationship between expression of ENO1 and lymph node metastasis and postradiotherapy distant metastasis (P>0.05).
CONCLUSION
The results show that ENO1 over expression may play a important role in cell proliferation and canceration of nasopharyngeal cancer.
目的
研究鼻咽癌组织中ENO1表达的意义。
方法
采用SP免疫组化方法。
结果
鼻咽癌组织中ENO1阳性表达率为60.0%，显著高于炎性鼻咽黏膜的阳性表达率（27.5%，11/40）（P<0.05）。T1+T2+T3期患者ENO1蛋白阳性表达率高于T4期患者（χ2=11.424，P<0.05）。但ENO1表达与淋巴结转移及放疗后远处转移无明显相关性（P>0.05）。
结论
结果表明ENO1过表达可能在鼻咽癌的细胞增殖和癌变中起重要作用。
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