Bazian A S, Grigir'ian G A, Ioffe M E
Usp Fiziol Nauk. 2011 Jul-Sep;42(3):65-80.
The review is devoted to analysis of the basic links of motor behavior control systems: sensorimotor cortex, cerebellum, a red nucleus and striatum. The organization and communications of these structures and their participation in learning and memory processes are described. The synaptic neurotransmitter and nonsynaptic neuromodulatory systems innervating these structures are also described. Hierarchical synaptic networks are formed by GABA and glutamatergic systems. The nonsynaptic dopaminergic system innervates both of these structures, but carries out a modulatory function. The mesocorticolimbic dopaminergic system induces an emotional and motivational state - processes of reinforcement, and participates in realization of purposeful behavior. The nigrostriatal dopaminergic system, through triggering an endocellular signal and the processes ofphosphorylation and dephosphorylation modulates activity ofGABA and glutamatergic receptors ofdorsal striatum spiny neurons and adapted thalamocortical networks.
感觉运动皮层、小脑、红核和纹状体。描述了这些结构的组织和通信及其在学习和记忆过程中的参与情况。还描述了支配这些结构的突触神经递质和非突触神经调节系统。GABA和谷氨酸能系统形成了分层突触网络。非突触多巴胺能系统支配这两种结构,但执行调节功能。中脑皮质边缘多巴胺能系统诱导情绪和动机状态——强化过程,并参与有目的行为的实现。黑质纹状体多巴胺能系统通过触发细胞内信号以及磷酸化和去磷酸化过程,调节背侧纹状体棘状神经元和适应性丘脑皮质网络的GABA和谷氨酸能受体的活性。