曾仅接受双侧肾上腺切除术治疗库欣病的患者对生长激素释放激素的生长激素反应。

The growth hormone response to growth hormone releasing hormone in patients previously treated with bilateral adrenalectomy alone for Cushing's disease.

作者信息

Whitehead H M, McKnight J A, Sheridan B, Kennedy A L, Hadden D R, Atkinson A B

机构信息

Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland.

出版信息

J Endocrinol Invest. 1990 Mar;13(3):217-20. doi: 10.1007/BF03349543.

DOI:10.1007/BF03349543

PMID:2195097

Abstract

Human growth hormone releasing hormone (GHRH) fails to stimulate human growth hormone (GH) in hypercortisolism. In order to study whether the responsiveness to GHRH stimulation returns after cure of the hypercortisolism, the GH response to GHRH was examined in 8 patients at least 5 yr after they had undergone bilateral adrenalectomy as their sole treatment for Cushing's disease. None had current evidence of a pituitary macroadenoma. A group of 8 healthy subjects matched for age and sex formed the control group. All patients and subjects received an iv injection of GHRH 1 microgram/kg, after an overnight fast, blood samples were taken before and at 15, 30, 45, 60, 90 and 120 min. There was no statistical difference between the peak GH or area under curve (AUC) response (median, range) in the two groups studied (adrenalectomized peak GH 9.2 (4.6-32.0) vs 16.5 (7.5-63) mU/l, adrenalectomized AUC response 647.5 (344.2-1489.5) vs 1103.5 (339.7-5188.5) mU/l. Patients with Cushing's disease once cured of hypercortisolism, have a GH response to GHRH.

摘要

在皮质醇增多症中，人类生长激素释放激素（GHRH）无法刺激人类生长激素（GH）分泌。为了研究在皮质醇增多症治愈后，对GHRH刺激的反应性是否恢复，对8例因库欣病仅接受双侧肾上腺切除术且至少5年的患者进行了GHRH刺激试验。所有患者目前均无垂体大腺瘤的证据。选取8名年龄和性别匹配的健康受试者作为对照组。所有患者和受试者在禁食过夜后静脉注射1微克/千克的GHRH，在注射前及注射后15、30、45、60、90和120分钟采集血样。在研究的两组中，峰值GH或曲线下面积（AUC）反应（中位数，范围）无统计学差异（肾上腺切除组峰值GH为9.2（4.6 - 32.0），对照组为16.5（7.5 - 63）mU/l；肾上腺切除组AUC反应为647.5（344.2 - 1489.5），对照组为1103.5（339.7 - 5188.5）mU/l）。库欣病患者一旦治愈皮质醇增多症，对GHRH会产生GH反应。