The Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center and CASE Medical School, Cleveland, Ohio, USA.
Ann N Y Acad Sci. 2011 Sep;1233:298-306. doi: 10.1111/j.1749-6632.2011.06136.x.
We studied the mechanisms of oscillopsia suppression in subjects with infantile nystagmus syndrome, fusion maldevelopment nystagmus syndrome, and acquired nystagmus (AN). Hypothetical possibilities for perceptual stability were the following: (1) epochs of clear and stable vision during foveation periods of nystagmus waveforms; (2) cancellation by efference copy of motor output; (3) a combination of the effects of both foveation-period stability and efference-copy cancellation; or (4) elevated motion-detection threshold and vision suppression. Observations, studies, and models of oscillopsia suppression allowed comparison of these possibilities. Data from individual subjects supported some of the putative hypotheses. However, only one hypothesis remained viable that could explain how all subjects maintained perceptual stability despite their different nystagmus types, waveforms, and variability. Robust suppression of oscillopsia was only possible using efference-copy feedback of the motor output containing these specific nystagmus signals to cancel that motion from the retinal error signals. In cases of AN, where oscillopsia could not be suppressed, the deficit was postulated to interfere with or lie outside of this efference-copy feedback loop.
我们研究了眼球震颤抑制的机制，包括婴儿性眼球震颤综合征、融合发育性眼球震颤综合征和获得性眼球震颤（AN）。知觉稳定的假设可能性如下：（1）在眼球震颤波形的注视期内有清晰稳定的视觉时期；（2）运动输出的传出副本的消除；（3）两者的结合，注视期稳定性和传出副本消除的效果；或（4）运动检测阈值升高和视觉抑制。眼球震颤抑制的观察、研究和模型允许对这些可能性进行比较。个体受试者的数据支持了一些假设。然而，只有一个假设仍然可行，它可以解释为什么所有受试者尽管他们的眼球震颤类型、波形和可变性不同，但仍能保持知觉稳定。只有使用包含这些特定眼球震颤信号的运动输出的传出副本反馈来消除视网膜误差信号中的这种运动，才能实现对眼球震颤的稳健抑制。在无法抑制眼球震颤的情况下，假设该缺陷干扰或位于该传出副本反馈回路之外。
