Tamaki N, Yamashita H, Kimura M, Ehara K, Asada M, Nagashima T, Matsumoto S, Hashimoto M
Department of Neurosurgery, School of Medicine, Kobe University, Japan.
J Neurosurg. 1990 Aug;73(2):274-8. doi: 10.3171/jns.1990.73.2.0274.
Changes in biological water components and their respective content in the cortical gray matter and periventricular white matter were studied in rabbits rendered hydrocephalic by intracisternal kaolin injection. There was no change in either total water content or free or bound water content in the cortical gray matter at the various stages of hydrocephalus development. While there was no significant change in total water content in the periventricular white matter at any stage of hydrocephalus, free water content was significantly elevated and bound water content was decreased at the acute and subacute stages, with a return to relatively normal levels at the chronic stage. It is concluded that in the periventricular white matter, free water enters the brain across the ependymal lining during the acute and subacute stages of experimental hydrocephalus with a simultaneous reduction in the bound water and that there is some recovery at the chronic stage. It is suggested that alternative drainage pathways may develop in chronic hydrocephalus allowing drainage of free water in the periventricular white matter, which in turn permits bound water to return to relatively normal levels.
通过脑池内注射高岭土使家兔发生脑积水，研究了皮质灰质和脑室周围白质中生物水成分及其各自含量的变化。在脑积水发展的各个阶段，皮质灰质中的总含水量、自由水或结合水含量均无变化。虽然在脑积水的任何阶段，脑室周围白质的总含水量均无显著变化，但在急性和亚急性期，自由水含量显著升高，结合水含量降低，在慢性期恢复到相对正常水平。得出的结论是，在实验性脑积水的急性和亚急性期，脑室周围白质中的自由水通过室管膜内衬进入大脑，同时结合水减少，在慢性期有一定程度的恢复。有人提出，在慢性脑积水中可能会形成替代引流途径，使脑室周围白质中的自由水得以引流，进而使结合水恢复到相对正常水平。
