Department of Neurology, University of Pécs, Pécs, Hungary.
Eur Neurol. 2011;66(4):220-6. doi: 10.1159/000330658. Epub 2011 Sep 23.
BACKGROUND/AIMS: We investigated adaptive reorganization in Parkinson's disease (PD) by fMRI using a passive movement task and compared the brain activation patterns of 10 patients with left- versus right-sided dominant symptoms. Five healthy controls were also investigated with the same settings.
We grouped patients according to the predominant side of symptoms; thus, a right-sided dominant and a left-sided dominant group was formed. The paradigm consisted of a 4-finger passive movement task, which altered with resting states. For each subject, this examination was performed twice: on the left and on the right hand separately.
In healthy controls, motor-related areas contralateral to the moving fingers showed activation on fMRI. Concerning PD patients, motor-related areas of the ipsilateral hemisphere - including the primary motor cortex, supplementary motor area, and basal ganglia - seemed to be involved in the motor reorganization in PD. However, we could only demonstrate this reorganization in patients with right-sided dominant symptoms.
We suggest that the human brain in PD tries to compensate for the failure of the basal ganglia motor loop by employing alternative (ipsilateral) motor pathways, indicating that a complex reorganization can also take place in disorders like PD which affect the whole motor-related network.
背景/目的：我们通过 fMRI 使用被动运动任务研究了帕金森病（PD）的适应性重组，并比较了 10 名左侧和右侧症状为主的患者的大脑激活模式。还对 5 名健康对照者进行了相同设置的研究。
我们根据症状的主要侧分组患者；因此，形成了右侧主导和左侧主导组。该范式包括 4 指被动运动任务，该任务随静息状态而改变。对于每个受试者，将该检查在左手和右手分别进行两次。
在健康对照者中，与运动手指相对侧的运动相关区域在 fMRI 上显示出激活。对于 PD 患者，同侧半球的运动相关区域 - 包括初级运动皮层、辅助运动区和基底节 - 似乎参与了 PD 中的运动重组。然而，我们仅在右侧主导症状的患者中证明了这种重组。
我们建议 PD 中的人脑试图通过使用替代（同侧）运动途径来补偿基底节运动回路的失败，表明复杂的重组也可能发生在影响整个运动相关网络的疾病中，如 PD。
