Division of Hematology & Oncology and Rush University Cancer Center, Rush University Medical Center, Chicago, IL, USA.
Cancer J. 2011 Sep-Oct;17(5):283-93. doi: 10.1097/PPO.0b013e318232ff44.
Vaccines have shown promise for the prevention and treatment of solid tumors. Colorectal cancer and renal cell carcinoma are common malignancies that may be amenable to vaccine strategies. This review summarizes target antigens in colorectal and renal cell carcinoma, discusses some of the vaccine approaches in development, and details the results of pivotal phase III trials evaluating therapeutic vaccines in patients with advanced colorectal and renal cell carcinoma. Finally, some of the challenges with vaccine development for colorectal and renal cell carcinoma are described.
疫苗在预防和治疗实体瘤方面显示出了前景。结直肠癌和肾细胞癌是常见的恶性肿瘤，可能适合疫苗策略。本文综述了结直肠癌和肾细胞癌中的靶抗原，讨论了一些正在开发中的疫苗方法，并详细介绍了评估晚期结直肠癌和肾细胞癌治疗性疫苗的关键性 III 期临床试验的结果。最后，描述了结直肠癌和肾细胞癌疫苗开发所面临的一些挑战。
