具有生物活性的中氮茚衍生物III：3-(3-氨基丙基)-2-甲基中氮茚、3-(3-氨基丙基)-2-甲基-5,6,7,8-四氢中氮茚及其N-烷基衍生物。
Indolizine derivativatives with biological activity III: 3-(3-Aminopropyl)-2-methylindolizine, 3-(3-Aminopropyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and their N -alkyl derivatives.
作者信息
Antonini I, Cardellini M, Claudi F, Franchetti P, Gulini U, De Caro G, Venturi F
出版信息
J Pharm Sci. 1977 Dec;66(12):1692-6. doi: 10.1002/jps.2600661209.
PMID:21953
Abstract
The syntheses and a preliminary pharmacological evaluation of some aminopropylindolizines and aminopropyltetrahydroindolizines are reported. All compounds showed anti-5-hydroxytryptamine, anti-histamine, and antiacetylcholine activities. Some also exhibited weak CNS activity.
摘要
报道了一些氨丙基中氮茚和氨丙基四氢中氮茚的合成及初步药理评价。所有化合物均显示出抗5-羟色胺、抗组胺和抗乙酰胆碱活性。有些还表现出较弱的中枢神经系统活性。
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