Gillissen G, Schumacher M, Breuer-Werle M
Institut de Microbiologie Médicale, Faculté de Médecine, Université d'Aix-la-Chapelle.
Pathol Biol (Paris). 1990 May;38(5):436-40.
Imipenem (IMI) forming round cells in Gram negative rods reduces in subinhibitory concentrations (subMIC) the seroresistance of E. coli. This effect is distinctly more pronounced in a moderately seroresistant strain of E. coli than in a high seroresistant one. Conversely, human serum (HS) increases the sensitivity of E. coli strains to IMI dependent on their original seroresistance. In contrast, ampicillin (AMP), a filament inducer in E. coli, reduces equally seroresistance but only to a minimal degree and that only in a moderately seroresistant strain; the high seroresistant strain was nonreactive in this respect. It was concluded, that a synergism of antibiotics and bactericidal serum effect is predominantly produced with round cell forming antibiotics, whereas filament forming ones show only minimal effects. Moreover, the original seroresistance of strains in apparently important for the degree tho which these phenomena are expressed.
亚胺培南（IMI）在革兰氏阴性杆菌中形成圆形细胞，在亚抑菌浓度（亚MIC）下可降低大肠杆菌的血清抗性。这种效应在中度血清抗性的大肠杆菌菌株中比在高血清抗性菌株中明显更显著。相反，人血清（HS）根据大肠杆菌菌株原有的血清抗性增加其对IMI的敏感性。相比之下，氨苄西林（AMP）是大肠杆菌中的丝状诱导剂，同等程度地降低血清抗性，但仅在中度血清抗性菌株中降至最低程度，高血清抗性菌株在这方面无反应。得出的结论是，抗生素与杀菌血清效应的协同作用主要由形成圆形细胞的抗生素产生，而形成丝状细胞的抗生素仅显示出最小的效应。此外，菌株原有的血清抗性对于这些现象的表达程度显然很重要。
