Class II alleles HLA-DQB1* 0301 among a seven-membered Egyptian family of a child with oral pemphigoid.

OBJECTIVES

The presence of HLA-DBQ1* 0301 allele in an Egyptian patient with oral pemphigoid and six of his family members was investigated.

BACKGROUND

Oral pemphigoid is a variant of vesiculobullous mucous membrane pemphigoid with an immunogenetic predisposition related to defects in major histocompatibility complex (OMIM 604305), HLA-DQB 1 alleles.

METHODS

High resolution typing of HLA-DQB 1*0301 allele was carried out for the seven members of an Egyptian family including the child affected with oral pemphigoid.

RESULTS

Both parents and three children including the proband were found to be carriers for the studied allele, while the other two children were not.

CONCLUSION

Participation of HLA-DBQ1*0301 allele was not informative for both susceptibility and/or phenotypic expression of the disease within the studied family (Fig. 2, Ref. 31).