Research School of Biology, Australian National University, Canberra, ACT 0200, Australia.
Biochem J. 2011 Oct 15;439(2):e1-2. doi: 10.1042/BJ20111484.
Metabolism in tumour cells is adapted to the demands of a growing cell. The Warburg effect and increased use of glutamine are two well-known adaptations of tumour metabolism. Both require transporters to allow uptake of substrates and efflux of products. Differentiated cells are less reliant on these pathways and as a result are less vulnerable to drugs that curtail nutrient uptake. Thus drugs that reduce nutrient uptake are promising candidates for tumour therapy. Detailed understanding of tumour cell biology will allow the generation of new chemotherapeutic drugs with limited side effects.
肿瘤细胞的代谢适应了细胞生长的需求。众所周知，肿瘤代谢的两个适应性变化为瓦博格效应和谷氨酰胺的大量利用。这两者都需要转运蛋白来允许底物的摄取和产物的外排。分化细胞对这些途径的依赖性较低，因此对限制营养摄取的药物的敏感性较低。因此，减少营养摄取的药物是肿瘤治疗的有前途的候选药物。对肿瘤细胞生物学的深入了解将允许生成具有有限副作用的新型化疗药物。
