Korea Artificial Organ Center, Korea University Medical College, Seoul, Korea.
Artif Organs. 2011 Nov;35(11):1123-6. doi: 10.1111/j.1525-1594.2011.01350.x. Epub 2011 Sep 29.
Blood viscosity during operation of ventricular assist device (VAD) can be changed by various conditions such as anemia. It is known generally that the blood viscosity can affect vascular resistance and lead to change of blood flow. In this study, the effect of fluid viscosity variation on hemodynamic energy was evaluated with a pulsatile blood pump in a mock system. Six solutions were used for experiments, which were composed of water and glycerin and had different viscosities of 2, 2.5, 3, 3.5, 4, and 4.5 cP. The hemodynamic energy at the outlet cannula was measured. Experimental results showed that mean pressure was increased in accordance with the viscosity increase. When the viscosity increased, the mean pressure was also increased. However, the flow was decreased according to the viscosity increase. Energy equivalent pressure value was increased according to the viscosity-induced pressure rise; however, surplus hemodynamic energy value did not show any apparent changing trend. The hemodynamic energy made by the pulsatile VAD was affected by the viscosity of the circulating fluid.
心室辅助装置（VAD）手术过程中的血液粘度会因贫血等各种情况而发生变化。一般来说，血液粘度会影响血管阻力，导致血流量发生变化。在这项研究中，使用脉动血泵在模拟系统中评估了流体粘度变化对血液动力学能量的影响。实验使用了六种由水和甘油组成、粘度分别为 2、2.5、3、3.5、4 和 4.5 cP 的溶液。测量了出口插管处的血液动力学能量。实验结果表明，平均压力随粘度的增加而升高。当粘度增加时，平均压力也随之升高。然而，随着粘度的增加，流量减少。能量等效压力值随粘度引起的压力升高而增加；然而，剩余的血液动力学能量值没有表现出明显的变化趋势。脉动 VAD 产生的血液动力学能量受到循环流体粘度的影响。
