Tatlipinar Sinan, Dinç Umut Aslı, Yenerel N Melda, Görgün Ebru
Department of Ophthalmology, Yeditepe University Medical Faculty, Balmumcu, Besiktas, İstanbul, Turkey.
Clin Exp Optom. 2012 Jan;95(1):94-8. doi: 10.1111/j.1444-0938.2011.00662.x. Epub 2011 Sep 28.
The aim was to investigate the short-term effects of a single intravitreal bevacizumab injection on the retinal vessel calibre in patients with neovascular age-related macular degeneration and in patients with diabetic macular oedema.
Twelve patients with neovascular age-related macular degeneration and eight patients with diabetic macular oedema were included in the study. All patients received an intravitreal injection of 1.25 mg bevacizumab. Red-free fundus photographs (35°) were acquired with a fundus camera at baseline and one day, one week and one month after the intravitreal injection. Measurements of retinal vessel diameter were made of the supero-temporal retinal venule and arteriole using the software available on the IMAGEnet program.
Although there appeared to be a trend towards vasoconstriction for the measurements in the diabetic macular oedema group (both for arterioles and venules at day 7) and the age-related macular degeneration group (for venules at day 1 and for arterioles at day 7), it did not reach statistical significance (p > 0.05). Optical coherence tomography revealed a significant decrease in foveal thickness measurements in both groups at the one month visit compared with baseline.
The results suggest that intravitreal injection of bevacizumab might induce retinal vasoconstriction; however, low numbers of subjects might have prevented the difference from reaching statistical significance. Further studies with a larger number of subjects would reveal the effect of intravitreal anti-vascular endothelial growth factor treatment on retinal vessel diameters more clearly.
本研究旨在探讨单次玻璃体内注射贝伐单抗对新生血管性年龄相关性黄斑变性患者及糖尿病性黄斑水肿患者视网膜血管管径的短期影响。
本研究纳入了12例新生血管性年龄相关性黄斑变性患者和8例糖尿病性黄斑水肿患者。所有患者均接受了1.25mg贝伐单抗的玻璃体内注射。在基线时以及玻璃体内注射后1天、1周和1个月，使用眼底相机拍摄无赤眼底照片（35°）。使用IMAGEnet程序上的软件测量颞上视网膜小静脉和小动脉的视网膜血管直径。
尽管糖尿病性黄斑水肿组（第7天的小动脉和小静脉）和年龄相关性黄斑变性组（第1天的小静脉和第7天的小动脉）的测量结果似乎有血管收缩的趋势，但未达到统计学显著性（p>0.05）。光学相干断层扫描显示，与基线相比，两组在1个月随访时黄斑中心凹厚度测量值均显著降低。
结果表明，玻璃体内注射贝伐单抗可能会诱导视网膜血管收缩；然而，受试者数量较少可能阻止了差异达到统计学显著性。更多受试者参与的进一步研究将更清楚地揭示玻璃体内抗血管内皮生长因子治疗对视网膜血管直径的影响。
