Rashid Taha, Ebringer Alan
Analytical Sciences Group, Kings College London, London SE1 9NN, United Kingdom.
Discov Med. 2011 Sep;12(64):187-94.
Ankylosing spondylitis (AS) and Crohn's disease (CD), especially when associated with spondylitis are interrelated conditions included within the categories of spondyloarthropathic disease entities. They share some common clinical, genetic, and microbiological findings. An extensive amount of studies which have been carried out by various independent groups throughout the world have shown that Klebsiella pneumoniae microorganisms could be suggested as the most likely etiopathogenetic triggers for AS and CD based on the molecular mimicry mechanism and the existence of the evidence for immunological, microbiological, and molecular link between Klebsiella and self antigens. It is proposed that the use of low starch diet in conjunction with the currently used treatment might help in the eradication of Klebsiella microbes from the bowel and could result in the stoppage and alleviation of the disease process in patients with AS and/or CD.
强直性脊柱炎（AS）和克罗恩病（CD），尤其是与脊柱炎相关时，是脊柱关节病疾病实体类别中的相关病症。它们有一些共同的临床、遗传和微生物学表现。世界各地不同独立研究小组进行的大量研究表明，基于分子模拟机制以及肺炎克雷伯菌与自身抗原之间存在免疫、微生物和分子联系的证据，肺炎克雷伯菌微生物可能是AS和CD最可能的病因触发因素。有人提出，低淀粉饮食与目前使用的治疗方法相结合，可能有助于从肠道根除克雷伯菌微生物，并可能导致AS和/或CD患者的疾病进程停止和缓解。
