Hardebo J E, Edvinsson L
Stroke. 1979 Jan-Feb;10(1):58-62. doi: 10.1161/01.str.10.1.58.
Adenosine and adenine compounds (AMP, cyclic AMP, ADP and ATP) markedly dilated feline and human pial arteries in vitro, the effect being more prominent with increasing tone of the vessel (active tonic contraction induced by prostaglandin F 2 alpha or serotonin). In contrast, the various adenine compounds were unable to produce any dilation of extracranial arteries tested (branches of lingual, external maxillary, and superficial temporal arteries). The degree of dilatation depended upon the perivascular potassium concentration, so that low potassium increased Emax and reduced ED50 values. Possible involvement of adenine compounds in the vasodilatory phase of the migraine attack is discussed.
腺苷和腺嘌呤化合物（AMP、环磷酸腺苷、ADP和ATP）在体外能显著扩张猫和人的软脑膜动脉，随着血管张力增加（由前列腺素F2α或血清素诱导的主动紧张性收缩），这种作用更为显著。相比之下，各种腺嘌呤化合物对所测试的颅外动脉（舌动脉、上颌外动脉和颞浅动脉的分支）没有产生任何扩张作用。扩张程度取决于血管周围钾离子浓度，因此低钾会增加最大效应（Emax）并降低半数有效剂量（ED50）值。文中讨论了腺嘌呤化合物在偏头痛发作血管舒张期可能的作用。
