Departamento de Biodinâmica do Movimento do Corpo Humano, Escola de Educação Física e Esporte, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 2011 Sep;44(9):827-35. doi: 10.1590/s0100-879x2011007500075. Epub 2011 Jun 1.
Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training.
心力衰竭是多种心血管疾病的常见终点，也是发病率和死亡率的重要原因。慢性神经体液兴奋（即，交感神经活性亢进）被认为是心力衰竭的标志，并与预后不良、心功能和重塑以及骨骼肌病相关。有氧运动训练在对抗交感神经活性亢进及其对心脏和骨骼肌的毒性作用方面非常有效。在这篇综述中，我们描述了有氧运动训练对人类和动物心力衰竭患者的交感神经活性亢进、骨骼肌病以及心功能和重塑的影响。我们还讨论了有氧运动训练效果的潜在机制。
