Renal Division, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China.
Clin Chim Acta. 2012 Jan 18;413(1-2):187-91. doi: 10.1016/j.cca.2011.09.018. Epub 2011 Sep 17.
To evaluate the value of basal urinary L-FABP (uL-FABP) excretion as a prognostic indicator of the progression of kidney function impairment in patients with chronic glomerulonephritis (CGN).
One hundred twenty-three patients with newly diagnosed, biopsy-proven primary CGN were included. In all patients, and in 28 healthy subjects, uL-FABP was measured using an ELISA. Risk factors of the progression of kidney function were evaluated. The patients were in follow-up for at least 5 years.
uL-FABP in the patients with CGN (76.58±17.3 μg/g.cr) was greater than in the healthy subjects. A significant positive correlation between uL-FABP and proteinuria (R=0.501, P<0.01), serum creatinine (R=0.601, P<0.01) were found. Kaplan-Meier analysis revealed that uL-FABP >76.58 μg/g.cr predicts progression of renal function. The cut off values for L-FABP at 119.8 μg/g.cr was found to be more sensitive, area under the curve (AUC) was 0.95.
Urinary L-FABP may be a useful clinical biomarker for monitoring chronic glomerular disease. Urinary L-FABP can help predict the progression of chronic glomerular disease.
评估基础尿 L-FABP（uL-FABP）排泄作为慢性肾小球肾炎（CGN）患者肾功能损害进展的预后指标的价值。
纳入 123 例新诊断、经活检证实的原发性 CGN 患者。在所有患者和 28 名健康受试者中，均使用 ELISA 测量 uL-FABP。评估肾功能进展的危险因素。患者至少随访 5 年。
CGN 患者的 uL-FABP（76.58±17.3 μg/g.cr）高于健康受试者。uL-FABP 与蛋白尿（R=0.501，P<0.01）、血清肌酐（R=0.601，P<0.01）呈显著正相关。Kaplan-Meier 分析显示，uL-FABP >76.58 μg/g.cr 预测肾功能进展。发现 L-FABP 的截断值为 119.8 μg/g.cr 更敏感，曲线下面积（AUC）为 0.95。
尿 L-FABP 可能是监测慢性肾小球疾病的有用临床生物标志物。尿 L-FABP 有助于预测慢性肾小球疾病的进展。
