Department of Biochemistry and Molecular Biology, Sciences II, 30 Quai Ernest-Ansermet, CH 1211 Geneva 4, Switzerland.
Curr Opin Genet Dev. 2011 Dec;21(6):690-5. doi: 10.1016/j.gde.2011.09.002. Epub 2011 Sep 28.
In the wing imaginal disc of Drosophila melanogaster, the morphogen Dpp controls growth, probably in an instructive manner. Many models for growth control by Dpp have been proposed and have been extensively discussed elsewhere. In this review, we speculate on how instructive growth control could provide a link between Dpp signaling and cell growth and/or cell cycle progression and so implement morphogenetic growth control on the cellular and molecular levels.
在果蝇的翅 imaginal 盘，形态发生素 Dpp 控制生长，可能以指导的方式。已经提出了许多 Dpp 控制生长的模型，并在其他地方进行了广泛的讨论。在这篇综述中，我们推测指导生长控制如何在 Dpp 信号和细胞生长和/或细胞周期进展之间提供联系，从而在细胞和分子水平上实现形态发生生长控制。
