Yoshida Daisuke, Nagao Yoshihiro, Tomikawa Morimasa, Kawanaka Hirofumi, Akahoshi Tomohiko, Kinjo Nao, Uehara Hideo, Hashimoto Naotaka, Hashizume Makoto, Maehara Yoshihiko
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, Fukuoka, Japan.
Hepatol Int. 2012 Jun;6(3):657-61. doi: 10.1007/s12072-011-9315-6. Epub 2011 Sep 30.
The purpose of our study was to investigate predictive factors for platelet count at 1 month after splenectomy in patients with liver cirrhosis.
A total of 60 patients with liver cirrhosis who were treated with splenectomy from January 2005 to December 2006 were enrolled in the study (hepatitis C, n = 50; hepatitis B, n = 6; alcoholism, n = 2; others, n = 2). Various preoperative clinical characteristics, including spleen weight, were analyzed by simple and multiple linear regressions to study the relationship between platelet count before and after splenectomy.
Platelet count increased significantly after splenectomy. After simple linear regression, spleen weight, preoperative platelet count, lymphocyte count, and total bilirubin were significantly correlated with platelet count after splenectomy. Spleen weight, preoperative platelet count, and lymphocyte count also had a significant correlation after multiple linear regression analysis.
Platelet count after splenectomy in cirrhotic patients can be predicted on the basis of preoperative clinical characteristics. When selecting patients for splenectomy, spleen weight, preoperative platelet count, and lymphocyte count should be taken into consideration.
我们研究的目的是调查肝硬化患者脾切除术后1个月血小板计数的预测因素。
选取2005年1月至2006年12月期间接受脾切除术治疗的60例肝硬化患者纳入研究（丙型肝炎，n = 50；乙型肝炎，n = 6；酒精性肝病，n = 2；其他，n = 2）。通过简单线性回归和多元线性回归分析各种术前临床特征，包括脾脏重量，以研究脾切除术前、后血小板计数之间的关系。
脾切除术后血小板计数显著增加。简单线性回归后，脾脏重量、术前血小板计数、淋巴细胞计数和总胆红素与脾切除术后血小板计数显著相关。多元线性回归分析后，脾脏重量、术前血小板计数和淋巴细胞计数也具有显著相关性。
肝硬化患者脾切除术后的血小板计数可根据术前临床特征进行预测。在选择脾切除患者时，应考虑脾脏重量、术前血小板计数和淋巴细胞计数。
