移植肾肾小球病：它并不总是与慢性排斥反应有关。

Transplant glomerulopathy: it's not always about chronic rejection.

出版信息

Kidney Int. 2011 Oct;80(8):801-3. doi: 10.1038/ki.2011.192.

DOI:10.1038/ki.2011.192

PMID:21960169

Abstract

Transplant glomerulopathy (TG) is a morphologic lesion of renal allografts characterized by duplication of the glomerular basement membrane and is widely accepted as a manifestation of chronic antibody-mediated rejection (AMR). However, TG is not specific for chronic AMR, and this pattern of injury may result from a number of disease processes affecting the glomerular endothelium. Baid-Agrawal and co-workers consider three different, but not mutually exclusive, processes that can produce morphologic lesions of TG: chronic AMR, hepatitis C, and thrombotic microangiopathy.

摘要

移植性肾小球病（TG）是一种肾移植的形态学病变，其特征为肾小球基底膜的复制，被广泛认为是慢性抗体介导的排斥反应（AMR）的表现。然而，TG 并非慢性 AMR 所特有，这种损伤模式可能是由影响肾小球内皮的许多疾病过程引起的。Baid-Agrawal 及其同事认为，有三种不同的但不相互排斥的过程可以产生 TG 的形态学病变：慢性 AMR、丙型肝炎和血栓性微血管病。