Kawakami Yosuke, Toda Tamaki, Nishimura Toshinao, Sakane Junichi, Kuraoka Kazuya, Takehara Kazuhiro, Mizunoe Tomoya, Taniyama Kiyomi
Institute for Clinical Research, National Hospital Organization Japan, Kure Medical Center/Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure-City, Hiroshima 737-0023, Japan.
Patholog Res Int. 2011;2011:743836. doi: 10.4061/2011/743836. Epub 2011 Sep 22.
Conventional Papanicolaou smear method is still commonly used for cervical cancer screening in Japan, despite the liquid-based cytology (LBC) that has become a global tendency in the world recently. One of the obstacles in the way of popularization of this method seems to be the confusion as to diagnosis upon cervical glandular lesions. We performed comparison study between LBC and conventional Papanicolaou smear about cytological diagnosis using split-sample method in 4522 patients. In 13 cases analyses, which were reported with either AGC or adenocarcinoma by either method, LBC tends to be milder than that by conventional smear, however, the credibility of LBC is considered to be near to that of conventional smear with regard to screening for glandular abnormalities. These results indicate that cervical cancer screening should shift to LBC under the enough experience and appropriate dealing with the cytological diagnosis.
尽管液基细胞学检查(LBC)最近已成为全球趋势,但传统巴氏涂片法在日本仍常用于宫颈癌筛查。该方法普及的障碍之一似乎是对宫颈腺病变诊断的混淆。我们采用分样法对4522例患者的LBC和传统巴氏涂片进行了细胞学诊断的比较研究。在13例两种方法均报告为AGC或腺癌的分析中,LBC的诊断倾向于比传统涂片更轻,然而,在筛查腺异常方面,LBC的可信度被认为与传统涂片相近。这些结果表明,在有足够经验并适当处理细胞学诊断的情况下,宫颈癌筛查应转向LBC。