Vadillo Buenfil Manuel, Vela Ojeda Jorge, Galindo Rodríguez Griselda, Salazar Exaire Daniel
Unidad de Investigación en Epidemiología, Clínica y Departamento Clínico de Endocrinología, Hospital de Especialidades Antonio Fraga Mouret, Centro Médico La Raza, IMSS, México, DF.
Ginecol Obstet Mex. 2005 Feb;73(2):99-104.
Leptin is a protein hormone synthesized and secreted by adipose tissue and also probably in other organs and systems in human body. It has multiple functions such as to regulate feed intake and energy balance, gonadal regulation, action in the hypothalamo-pituitary-gonadal axis, regulates the metabolism of the fetal-placental unit in the pregnancy, fertility and reproductive systems, actions in the endometrium, mammary gland with corresponding influences on important physiologic processes such as menstruation, pregnancy and lactation. In the gynecologic surgery the serum leptin concentration is also modified. The knowledge of serum leptin concentration in the oncological diseases is going-up. Leptin is modified in the choriocarcinoma, Meigs' syndrome and other tumors. A better understanding of regulatory mechanisms will have direct clinical significance, as leptin has been proposed to impact on those causes of human perinatal morbidity and mortality that are associated with abnormalities of fetal maturity and development, general concept growth, trophoblast endocrinology, and placental sufficiency. Further investigations in this area will be necessary to improve new knowledge and a better understanding of the actions about this hormone.
瘦素是一种由脂肪组织合成并分泌的蛋白质激素，人体其他器官和系统可能也会分泌。它具有多种功能，如调节食物摄入和能量平衡、性腺调节、在下丘脑-垂体-性腺轴中的作用、调节孕期胎儿-胎盘单位的代谢、生育能力和生殖系统、在子宫内膜、乳腺中的作用，并对月经、怀孕和哺乳等重要生理过程产生相应影响。在妇科手术中，血清瘦素浓度也会发生改变。人们对肿瘤疾病中血清瘦素浓度的了解正在增加。在绒毛膜癌、梅格斯综合征和其他肿瘤中，瘦素会发生改变。更好地理解调节机制将具有直接的临床意义，因为瘦素已被认为会影响那些与胎儿成熟和发育异常、总体概念生长、滋养层内分泌以及胎盘功能不全相关的人类围产期发病和死亡原因。有必要在这一领域进行进一步研究，以增进新知识并更好地理解这种激素的作用。
