Cervero Ana, Domínguez Francisco, Horcajadas José A, Quiñonero Alicia, Pellicer Antonio, Simón Carlos
Fundacion IVI, Instituto Universitario IVI, University of Valencia, Spain.
Curr Opin Obstet Gynecol. 2006 Jun;18(3):297-303. doi: 10.1097/01.gco.0000193004.35287.89.
Since its discovery in 1994, leptin has appeared to be a pleiotrophic hormone, governing energy homeostasis and affecting many tissues in the body. Numerous pieces of evidence have accumulated showing that leptin potentially plays an important role in the control of the reproductive function.
This review presents the major concepts for the role of leptin in the modulation of reproductive function. As a marker of the nutritional status, leptin affects the hypothalamo-pituitary-gonadal axis, regulating gonadotrophin-releasing hormone and luteinising hormone secretion, and appears to be a permissive factor in the onset of the puberty. This protein and its receptor have been found in the reproductive tissues, indicating that this system could be also implicated in several processes such as embryo development, implantation and pregnancy. Moreover, disorders of the leptin system have been related to some reproductive pathologies such as pre-eclampsia and polycystic ovary syndrome. However, controversy surrounds several aspects of the action of leptin in reproduction that require a deeper investigation of this system.
Results to date suggest that this system could be implicated in important reproductive processes such as embryonic development and implantation. Moreover, understanding the role of leptin might be useful for new treatments in reproductive pathologies.
自1994年被发现以来，瘦素似乎是一种多效性激素，它调节能量平衡并影响身体的许多组织。大量证据表明，瘦素可能在生殖功能的控制中发挥重要作用。
本综述介绍了瘦素在调节生殖功能中作用的主要概念。作为营养状况的标志物，瘦素影响下丘脑-垂体-性腺轴，调节促性腺激素释放激素和促黄体生成素的分泌，并且似乎是青春期启动的一个允许因素。在生殖组织中发现了这种蛋白质及其受体，这表明该系统也可能参与胚胎发育、着床和妊娠等多个过程。此外，瘦素系统紊乱与一些生殖病理状况有关，如先兆子痫和多囊卵巢综合征。然而，瘦素在生殖中作用的几个方面仍存在争议，需要对该系统进行更深入的研究。
迄今为止的结果表明，该系统可能参与胚胎发育和着床等重要生殖过程。此外，了解瘦素的作用可能有助于生殖病理状况的新治疗。
