Ruiz Anguas Julián, Carballo Mondragón Esperanza, Durán Monterrosas Leonor, Kably Ambe Alberto
Unidad de Reproducción Asistida, Centro Especializado para la Atención de la Mujer, Hospital Angeles de la Lomas.
Ginecol Obstet Mex. 2005 Mar;73(3):137-44.
To perform a statistical analysis with variables that have influence on pregnancy rates to establish a prognostic factor of each one.
We performed a retrospective, descriptive, and observational study with 240 patients that underwent to IVF-ET program. The analyzed variables were: infertility factor, ovarian stimulation protocol, age of patients, basal hormonal levels, oestradiol preovulatory levels, endometrial characteristics, fertilization rate, number and quality of oocytes, number and quality of embryos, and difficulty of the embryo transfer.
The mean age of the patients was 34 +/- 4.42 years old. Tubal and pelvic pathologies were the main infertility cause. During the statistical analysis we observed that the only variables with differences regarding pregnancy were the number of cells in the embryo (7.18 vs 5.9), the fertilization rate (58.3 vs 50.1%), and the number of transferred embryos. With the logistic regression analysis we observed that the number of cells on each embryo had a relative risk of 1.37 (CI 95%; 1.15-1.63), and that the number of transferred embryos had one of 1.63 (CI 95%; 1.10-1.58).
There are many variables that influence the pregnancy rates, but with our results we consider that the embryo quality, its characteristics and the number of transferred embryos could predict better the possibilities of pregnancy in IVF-ET programs.
对影响妊娠率的变量进行统计分析，以确定每个变量的预后因素。
我们对240例行体外受精-胚胎移植（IVF-ET）程序的患者进行了一项回顾性、描述性观察研究。分析的变量包括：不孕因素、卵巢刺激方案、患者年龄、基础激素水平、排卵前雌二醇水平、子宫内膜特征、受精率、卵母细胞数量和质量、胚胎数量和质量以及胚胎移植难度。
患者的平均年龄为34±4.42岁。输卵管和盆腔病变是主要的不孕原因。在统计分析中，我们观察到与妊娠相关存在差异的唯一变量是胚胎中的细胞数量（7.18对5.9）、受精率（58.3%对50.1%）以及移植胚胎的数量。通过逻辑回归分析，我们观察到每个胚胎的细胞数量相对风险为1.37（95%置信区间；1.15 - 1.63），移植胚胎数量的相对风险为1.63（95%置信区间；1.10 - 1.58）。
有许多变量影响妊娠率，但根据我们的结果，我们认为胚胎质量、其特征以及移植胚胎的数量能够更好地预测IVF-ET程序中的妊娠可能性。
