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[伴有脂肪肉瘤分化的恶性叶状肿瘤。1例报告及文献复习]

[Malignant phyllodes tumor with differentiation to liposarcoma. A report of a case and bibliographic review].

作者信息

Argáez Cimé Noel Lorenzo, Gutiérrez Vega Pablo, López Cruz Jaime

机构信息

Serivico de Ginecología, Escuela Militar de Graduados de Sanidad, Periférico y Ejército Nacional, México, DF.

出版信息

Ginecol Obstet Mex. 2005 Mar;73(3):145-50.

Abstract

Phyllodes tumor represents less than 1% of breast tumors and 2 to 3% of the fibroepithelial tumors. The malignancy characteristics are the excessive growth and the stromal atypia with numerous mitosis. The stromal component of the phyllodes tumor has potential to cause metaplasia to bone tissue, cartilage, and to smooth and striated muscle, including their respective malignant neoplasms. The liposarcomatous differentiation of phyllodes tumor is extremely rare. We present the case of an unusual breast tumor diagnosed as phyllodes tumor, with sarcomatous changes on its stroma, which consists of pleomorfic and myxoid liposarcoma. We also comment some generalities about clinical and diagnostic aspects, as well as anatomopathological, therapeutic, and prognostic characteristics related to the current literature.

摘要

叶状肿瘤占乳腺肿瘤的比例不到1%,占纤维上皮性肿瘤的2%至3%。其恶性特征为过度生长以及伴有大量核分裂的间质异型性。叶状肿瘤的间质成分有可能化生为骨组织、软骨以及平滑肌和横纹肌,包括它们各自的恶性肿瘤。叶状肿瘤的脂肪肉瘤样分化极为罕见。我们报告一例罕见的乳腺肿瘤,诊断为叶状肿瘤,其间质有肉瘤样改变,由多形性和黏液样脂肪肉瘤组成。我们还对临床和诊断方面的一些一般性情况,以及与当前文献相关的解剖病理学、治疗和预后特征进行了评论。

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