Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ann Allergy Asthma Immunol. 2011 Oct;107(4):360-3. doi: 10.1016/j.anai.2011.07.010. Epub 2011 Sep 8.
The pathophysiology of upper airway cough syndrome is not well understood.
To investigate the levels of neuropeptides found in nasal mucus of subjects with and without the complaint of chronic cough.
Preformed nasal mucus from 26 subjects complaining of postnasal drip with chronic cough and 17 without self-reported chronic cough was collected at the time of presentation. The nasal secretions were assayed for 3 neuropeptides-substance P (SP), calcitonin gene-related peptide (CGRP), and Neurokinin A (NKA)-that have been previously linked to chronic cough.
Coughing subjects with postnasal drip have significantly higher levels of CGRP and SP than noncoughing subjects with postnasal drip (69.0 ng vs 4.6 ng, P < .001 and 4.5 ng vs 3.4 ng, P = .004). The differences in NKA levels in nasal secretions between coughing and noncoughing subjects did not reach statistical significance (16.3 ng vs 3.4 ng, P = .067).
Both CGRP and SP levels are elevated in preformed nasal secretions of coughing subjects when compared with noncoughing subjects. Additional studies are needed to clarify whether CGRP and SP levels in preformed nasal secretions may assist in diagnosis or predicting treatment response in patients presenting with chronic cough.
上气道咳嗽综合征的病理生理学尚不清楚。
研究有和无慢性咳嗽主诉的受试者鼻黏液中神经肽的水平。
在出现时，收集 26 名主诉鼻后滴注伴慢性咳嗽和 17 名无自报慢性咳嗽的受试者预先形成的鼻黏液。对先前与慢性咳嗽相关的 3 种神经肽——P 物质（SP）、降钙素基因相关肽（CGRP）和神经激肽 A（NKA）——进行鼻分泌物检测。
有鼻后滴注性咳嗽的受试者 CGRP 和 SP 水平明显高于无鼻后滴注性慢性咳嗽的受试者（69.0ng 对 4.6ng，P<0.001；4.5ng 对 3.4ng，P=0.004）。咳嗽和非咳嗽受试者的鼻分泌物中 NKA 水平差异无统计学意义（16.3ng 对 3.4ng，P=0.067）。
与非咳嗽受试者相比，咳嗽受试者的预先形成的鼻分泌物中 CGRP 和 SP 水平均升高。需要进一步的研究来阐明预先形成的鼻分泌物中的 CGRP 和 SP 水平是否有助于诊断或预测慢性咳嗽患者的治疗反应。
