Theoretical Biology and Bioinformatics Group, Department of Biology, Utrecht University, Padualaan 8, Utrecht, The Netherlands.
Curr Opin Genet Dev. 2011 Dec;21(6):799-805. doi: 10.1016/j.gde.2011.09.008. Epub 2011 Sep 29.
Feedback and integration of information are of paramount importance for the robust functioning and dynamics of biological systems. In plant developmental biology, experimentation is increasingly combined with computational modeling to obtain a better understanding of how such regulatory interactions shape the systems' behavior. Here we highlight experimental and modeling studies on feedback loops and integration mechanisms involved in plant development. These studies have substantially expanded our understanding of previously characterized gene regulatory networks (GRNs). In addition, they illustrate the pervasiveness of regulatory interactions between seemingly unrelated processes and levels of organization. Modelers in plant development will increasingly face the challenges of what level of detail, which processes and how many levels of organization to incorporate when trying to understand a particular process.
反馈和信息的整合对于生物系统的稳健运行和动态至关重要。在植物发育生物学中，实验越来越多地与计算建模相结合，以更好地理解这些调控相互作用如何塑造系统的行为。在这里，我们重点介绍了涉及植物发育的反馈回路和整合机制的实验和建模研究。这些研究极大地扩展了我们对先前表征的基因调控网络 (GRN) 的理解。此外，它们还说明了看似不相关的过程和组织层次之间的调控相互作用的普遍性。植物发育的建模者将越来越多地面临这样的挑战，即在试图理解特定过程时，应该纳入多少细节、哪些过程以及多少个组织层次。
