Cook M C, Taren D L
University of South Florida College of Public Health, Tampa.
J Fla Med Assoc. 1990 Jun;77(6):606-13.
Factors responsible for an increased risk of drug-nutrient interactions in the elderly are an increased exposure to drug use for chronic health conditions and the greater chance for marginal diets deficient in nutrients. Poor patient compliance and physicians' prescribing patterns further complicate the risk. Several nutrient-drug interactions cause changes in drug efficacy and affect nutritional status. To identify and assess elderly patients at risk, each should be evaluated through socioeconomic, dietary, and clinical parameters. The health-care team must be knowledgeable regarding drug interactions to properly intervene using a multidisciplinary approach. An intervention program could prevent a decline in the elderly's health status, reduce healthcare costs and improve the quality of life.
导致老年人药物与营养素相互作用风险增加的因素包括，因慢性健康状况而增加用药量，以及饮食中缺乏营养素的可能性更大。患者依从性差和医生的处方模式进一步增加了风险。几种营养素与药物的相互作用会导致药物疗效改变并影响营养状况。为了识别和评估有风险的老年患者，应通过社会经济、饮食和临床参数对每位患者进行评估。医疗团队必须了解药物相互作用，以便采用多学科方法进行适当干预。一个干预项目可以防止老年人健康状况下降，降低医疗成本并提高生活质量。
