Mazille N, Lipsker D, Fischbach M
Service de pédiatrie-1, hôpital de Hautepierre, CHRU de Strasbourg, 67098 Strasbourg, France.
Arch Pediatr. 2011 Nov;18(11):1201-4. doi: 10.1016/j.arcped.2011.08.011. Epub 2011 Oct 2.
We describe 3 cases of chronic purpuric skin lesions in children suffering from systemic vasculitis: 3 children with Henoch-Schönlein purpura. Dapsone was introduced when skin lesions were recurrent, extensive, and persistent, due to its known ability to act as an anti-IgA and as an anticytotoxic agent against polynuclear neutrophils. Fast and complete but purely suspensive healing of skin lesions was noted. One child developed methemoglobinemia, a known side-effect of dapsone, highlighting the need for adequate prescription and follow-up.
我们描述了3例患有系统性血管炎的儿童慢性紫癜性皮肤病变病例：3例患有过敏性紫癜的儿童。当皮肤病变复发、广泛且持续时，引入了氨苯砜，因为其已知具有抗IgA作用以及作为针对多核中性粒细胞的抗细胞毒性剂的能力。观察到皮肤病变迅速且完全愈合，但仅是暂时缓解。1名儿童出现了高铁血红蛋白血症，这是氨苯砜已知的副作用，突出了适当处方和随访的必要性。
