晚期早产儿脂蛋白亚类谱的早期产后变化。

Early postnatal changes of lipoprotein subclass profile in late preterm infants.

机构信息

Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Clin Chim Acta. 2012 Jan 18;413(1-2):109-12. doi: 10.1016/j.cca.2011.09.010. Epub 2011 Sep 22.

DOI:10.1016/j.cca.2011.09.010

PMID:21963460

Abstract

BACKGROUND

Late preterm infants (LPIs; 34-37 gestational weeks at birth) have higher risk for several morbidities than do term infants (TIs). It has been suggested that a cholesterol and fatty acid supply may improve their outcomes. We investigated the lipoprotein subclass profile in LPIs to evaluate their early postnatal lipid metabolism.

METHODS

Eighty-one infants (25 LPIs, 56 TIs) were included. Cholesterol and triglyceride (TG) concentrations in 12 lipoprotein subclasses were measured at birth and at 1 month using HPLC.

RESULTS

In LPIs, the cord blood exhibited higher cholesterol concentrations in medium and large subclasses of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) compared to the values in TIs. During the first month of life, LPIs had greater increases in cholesterol concentrations of medium and large subclasses of VLDL than TIs, whereas postnatal increases in cholesterol concentrations of medium and large subclasses of LDL and HDL were smaller. TG concentrations were not different in each VLDL subclass at birth and at 1 month.

CONCLUSIONS

In LPIs, cord blood lipoprotein subclass profiles and the early postnatal change exhibited different, especially in cholesterol concentrations.

摘要

背景

晚期早产儿（34-37 孕周出生）比足月儿有更高的多种疾病风险。有人提出，胆固醇和脂肪酸的供应可能会改善他们的结局。我们研究了晚期早产儿的脂蛋白亚类谱，以评估他们的新生儿后期脂质代谢情况。

方法

共纳入 81 名婴儿（25 名晚期早产儿，56 名足月儿）。使用 HPLC 技术在出生时和 1 个月时检测 12 种脂蛋白亚类的胆固醇和甘油三酯（TG）浓度。

结果

晚期早产儿的脐血中极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）的中、大颗粒胆固醇浓度均高于足月儿。在生命的第一个月，晚期早产儿的中、大颗粒 VLDL 胆固醇浓度增加幅度大于足月儿，而中、大颗粒 LDL 和 HDL 胆固醇浓度的增加幅度较小。出生时和 1 个月时，各 VLDL 亚类的 TG 浓度无差异。