Blumberg D A, Mink C M, Cherry J D, Reisinger K S, Blatter M M, Congeni B L, Dekker C L, Stout M G, Mezzatesta J R, Scott J V
Department of Pediatrics, University of California, Los Angeles School of Medicine 90024.
J Pediatr. 1990 Jul;117(1 Pt 1):46-51. doi: 10.1016/s0022-3476(05)82442-4.
Healthy 17- to 24-month-old children, previously immunized with three doses of whole-cell diphtheria-tetanus-pertussis (DTP) vaccine, were enrolled in a multi-center double-blind, randomized study comparing a DTP vaccine with an acellular pertussis-component (APDT) and a conventional whole-cell pertussis-component DTP vaccine. Thirty-eight children received APDT vaccine, and 37 children received DTP vaccine. APDT vaccine recipients had significantly less local pain and warmth than DTP vaccine recipients. Antibody responses to lymphocytosis-promoting factor were similar in the two groups. The APDT vaccine recipients had a higher IgG antibody response to filamentous hemagglutinin than the DTP vaccinees had. Equivalent agglutinin responses were seen in the two groups. The APDT vaccine recipients had a significantly better antibody re-enzyme-linked immunosorbent assay, than DTP vaccinees had 1 month and 1 year after immunization. This APDT vaccine was immunogenic and caused fewer local reactions than conventional DTP vaccine when administered as a fourth dose to 17- to 24-month-old children.
健康的17至24个月大儿童，此前已接种三剂全细胞白喉-破伤风-百日咳（DTP）疫苗，被纳入一项多中心双盲随机研究，该研究比较了一种DTP疫苗与一种无细胞百日咳成分（APDT）疫苗以及一种传统全细胞百日咳成分DTP疫苗。38名儿童接受了APDT疫苗，37名儿童接受了DTP疫苗。APDT疫苗接种者的局部疼痛和发热明显少于DTP疫苗接种者。两组对淋巴细胞增多促进因子的抗体反应相似。APDT疫苗接种者对丝状血凝素的IgG抗体反应高于DTP疫苗接种者。两组的凝集素反应相当。免疫后1个月和1年时，APDT疫苗接种者的抗体再酶联免疫吸附测定结果明显优于DTP疫苗接种者。这种APDT疫苗具有免疫原性，当作为第四剂给17至24个月大的儿童接种时，其引起的局部反应比传统DTP疫苗少。
