University of Rijeka, Department of Psychiatry and Psychological Medicine, Cambierieva 15, Rijeka, Croatia.
Psychiatr Danub. 2011 Sep;23(3):257-63.
The aim of this study was to evaluate the efficacy of tianeptine, an antidepressant that acts by increasing serotonin reuptake, in the treatment of posttraumatic stress disorder and to compare the effects of tianeptine and fluoxetine, an antidepressant from the selective serotonin reuptake inhibitors class.
43 war veterans suffering from posttraumatic stress disorder were included in the study. During the 5.5 months of treatment 21 patients were receiving tianeptine and 22 were receiving fluoxetine. In addition, all patients took part in intensive trauma specific group psychotherapy. The effects of the two antidepressants on symptoms of PTSD, depression and anxiety after 5.5 months of treatment were assessed using the Harvard Trauma Questionnaire, Beck Depression Inventory, STAI and the List of Drug Use and Side Effects.
There was no significant difference between the two treatment groups regarding their effect on symptoms and severity of depression. The level of anxiety was the same in the first measurement but the difference became significant in other three measurements in favor of tianeptine. The anxiolytics and other co-prescribed drugs remain the same in both groups, the use of analgesics significantly increase in fluoxetine group during the course of treatment.
The study demonstrated that tianeptine is as effective as fluoxetine in the treatment of PTSD, with even stronger effect on anxiety and equal tolerance.
本研究旨在评估噻奈普汀（一种通过增加 5-羟色胺再摄取而起作用的抗抑郁药）治疗创伤后应激障碍的疗效，并比较噻奈普汀和氟西汀（一种选择性 5-羟色胺再摄取抑制剂类抗抑郁药）的疗效。
43 名患有创伤后应激障碍的退伍军人参与了本研究。在 5.5 个月的治疗期间，21 名患者接受噻奈普汀治疗，22 名患者接受氟西汀治疗。此外，所有患者都参加了密集的创伤特异性团体心理治疗。使用哈佛创伤问卷、贝克抑郁量表、STAI 和药物使用和副作用清单评估两种抗抑郁药在治疗 5.5 个月后对 PTSD 症状、抑郁和焦虑的影响。
两组在改善抑郁症状和严重程度方面没有显著差异。在第一次测量时，焦虑水平相同，但在其他三次测量中，噻奈普汀的优势变得显著。两组的抗焦虑药和其他同时开的药物保持不变，在治疗过程中，氟西汀组的镇痛药使用显著增加。
该研究表明，噻奈普汀在治疗 PTSD 方面与氟西汀同样有效，对焦虑的疗效更强，且耐受性相同。
