Institute of Mathematics and Image Computing, University of Lübeck, Germany.
J Theor Biol. 2011 Dec 21;291:65-75. doi: 10.1016/j.jtbi.2011.09.012. Epub 2011 Sep 28.
The interaction between appetite activation and the energy content of the brain and the body is mathematically modeled. General influence functions with saturation are used to describe the interaction. The resulting class of models is investigated with respect to the circadian periodicity of human food intake. We show that very weak and physiologically reasonable assumptions on the constitutive functions are sufficient to validate the indispensable role of the brain as energy consumer in appetite regulation. Subsequently, implications from our systemic investigations of metabolic systems can be drawn although the quantification of the underlying regulatory pathways is uncertain, incomplete, or incompletely understood.
食欲激活与大脑和身体能量含量之间的相互作用被数学建模。使用具有饱和的通用影响函数来描述相互作用。对所得模型类进行了研究，以了解人类食物摄入的昼夜周期性。我们表明，对于构成函数的非常弱且生理合理的假设就足以验证大脑作为食欲调节中能量消耗者的不可或缺的作用。随后，可以从对代谢系统的系统研究中得出结论，尽管对基础调节途径的定量仍然不确定，不完整或不完全了解。
