Leibniz Institute for Farm Animal Biology (FBN), Nutritional Physiology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Mutat Res. 2012 May 1;733(1-2):61-8. doi: 10.1016/j.mrfmmm.2011.09.004. Epub 2011 Sep 22.
Coenzyme Q(10) (CoQ(10)) is an essential component for electron transport in the mitochondrial respiratory chain and serves as cofactor in several biological processes. The reduced form of CoQ(10) (ubiquinol, Q(10)H(2)) is an effective antioxidant in biological membranes. During the last years, particular interest has been grown on molecular effects of CoQ(10) supplementation on mechanisms related to DNA damage prevention. This review describes recent advances in our understanding about the impact of CoQ(10) on genomic stability in cells, animals and humans. With regard to several in vitro and in vivo studies, CoQ(10) provides protective effects on several markers of oxidative DNA damage and genomic stability. In comparison to the number of studies reporting preventive effects of CoQ(10) on oxidative stress biomarkers, CoQ(10) intervention studies in humans with a direct focus on markers of DNA damage are limited. Thus, more well-designed studies in healthy and disease populations with long-term follow up results are needed to substantiate the reported beneficial effects of CoQ(10) on prevention of DNA damage.
辅酶 Q(10)（CoQ(10)）是线粒体呼吸链中电子传递的必需组成部分，也是几种生物过程中的辅助因子。还原型辅酶 Q(10)（泛醇，Q(10)H(2)) 是生物膜中有效的抗氧化剂。在过去的几年中，人们对辅酶 Q(10)补充对与预防 DNA 损伤相关的机制的分子作用特别感兴趣。这篇综述描述了我们对 CoQ(10) 对细胞、动物和人类基因组稳定性影响的最新理解。关于几项体外和体内研究，CoQ(10)对几种氧化 DNA 损伤和基因组稳定性的标志物提供了保护作用。与报告 CoQ(10) 对氧化应激生物标志物的预防作用的研究数量相比，直接关注 DNA 损伤标志物的 CoQ(10) 干预研究在人类中受到限制。因此，需要在健康和患病人群中进行更多设计良好的研究，并进行长期随访，以证实报告的 CoQ(10) 对预防 DNA 损伤的有益作用。
