Adenovirus vaccine strains genetically engineered to express HIV-1 or HBV antigens for use as live recombinant vaccines.
作者信息
Hung P P, Chanda P K, Natuk R J, Mason B B, Chengalvala M, Bhat B M, Molnar-Kimber K L, Dheer S K, Morin J E, Mizutani S
机构信息
Wyeth-Ayerst Research, Philadelphia, Pa.
出版信息
Nat Immun Cell Growth Regul. 1990;9(3):160-4.
PMID:2196459
Abstract
Types 4 and 7 adenovirus are currently used as live, oral vaccines for the prevention of adenovirus respiratory disease in military recruits. These vaccine strains have been genetically engineered in order to express HIV-1 or HBV antigens in infected cells. A dog model was developed to evaluate the immunogenicity of these recombinant vaccines. Dogs inoculated with live adenovirus-HBV recombinant vaccine produced antibody against hepatitis B surface antigen.
摘要
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