Lemez P
Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia.
Neoplasma. 1990;37(3):253-66.
Acute leukemias are clonal malignant neoplastic diseases which do not originate from the transformation of totipotent hematopoietic stem cells but of progenitors committed to the myeloid, T-lymphatic or B-lymphatic differentiation lineage. The transforming event seems to be associated with a nonrandom aberrant DNA rearrangement. Although a leukemic population is clonal, originating from a single cell, it exhibits phenotypic, and sometimes even karyotypic, heterogeneity. Leukemic cells are allocated to a particular differentiation cell lineage on the basis of a positive finding of the lineage specific differentiation marker (LSDM) in the presented classification of acute leukemias. Criteria for common types of acute myeloid leukemias are described and the possible existence of several other types is discussed.
急性白血病是克隆性恶性肿瘤性疾病，并非起源于全能造血干细胞的转化，而是源于定向分化为髓系、T淋巴细胞系或B淋巴细胞系的祖细胞。转化事件似乎与非随机的异常DNA重排有关。尽管白血病群体是克隆性的，起源于单个细胞，但它表现出表型异质性，有时甚至是核型异质性。在急性白血病的现有分类中，根据谱系特异性分化标志物（LSDM）的阳性发现，将白血病细胞归为特定的分化细胞谱系。描述了常见类型急性髓系白血病的标准，并讨论了其他几种类型可能存在的情况。
