Lokhandwala M F, Hegde S S
Department of Pharmacology, University of Houston, TX 77204-5515.
Pharmacol Toxicol. 1990 Apr;66(4):237-43. doi: 10.1111/j.1600-0773.1990.tb00741.x.
Research efforts in the area of peripheral dopamine have now established the presence of two distinct subtypes--DA1 and DA2--of DA receptors, and have identified a potential role for dopamine produced within the kidney in the control of renal sodium excretion. Selective DA1 and DA2 receptor agonists are being developed because they exhibit therapeutic potential for treatment of cardiovascular and renal disorders. Furthermore, basic research efforts are aimed towards identifying the stimulus and/or stimuli for the production of dopamine within the kidney and characterizing the cellular signalling processes involved in mediating the renal effects of dopamine and selective DA receptor agonists.
外周多巴胺领域的研究工作现已证实存在两种不同的多巴胺（DA）受体亚型——DA1和DA2，并确定了肾脏产生的多巴胺在控制肾钠排泄方面的潜在作用。选择性DA1和DA2受体激动剂正在研发中，因为它们在治疗心血管和肾脏疾病方面具有治疗潜力。此外，基础研究工作旨在确定肾脏中多巴胺产生的刺激因素和/或刺激因素，并描述介导多巴胺和选择性DA受体激动剂对肾脏作用的细胞信号传导过程。
